Explore https://ligaz.bet/ Options
Explore https://ligaz.bet/ Options
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Ellenberger and co-workers (eight) had intuited just this kind of motion of your OB domain if they solved the crystal composition on the much larger human DNA ligase I (HuLig1; 919 amino acids) sure to an adenylylated nick. Their landmark composition was the main to document the circumferential envelopment from the DNA duplex by a ligase clamp and the resulting bending and distortion of your duplex that power the base pairs over the 3′-OH aspect of your nick into an RNA-like A helical conformation (8). Equivalent distortions were being observed while in the ChVLig·DNA complex (7).
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The movement entails a rigid entire body rotation in regards to the hinge segment connecting the NTase and OB domains (indicated with the arrow
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